Climate change and increasing population pressure make it increasingly urgent to find ways to improve the management of the water-energy nexus. The desalination, pumping, distribution, and treatment of water use significant energy resources. The extraction and production of energy consume substantial amounts of water resources. In addition, negative effects on the environment are often the consequences of the management of the water and energy sectors. The report highlights the prospects for addressing these and other challenges at the water-energy nexus. It does this by drawing, in part, on some of the most important breakthroughs in the nexus that have come from the region.