The objective of this Regional Economic Memorandum (REM) is to strengthen the economic analysis available to policymakers on the challenges and opportunities for regional economic integration to support job creation and economic transformation in the Horn of Africa. It assesses the current state of regional economic integration, how policies and investments can deepen this integration, and how this could help to address the opportunities and challenges confronting the region. The analysis applies both an economic geography perspective (based on the 3Ds framework of the 2009 WDR – density, distance, and division) and the lens of the jobs and economic transformation (JET) agenda, whilst taking into account fragility and conflict and the region’s complex and evolving political economy. This overview synthesizes the key findings of the analysis conducted for the HoA REM, full details of which are presented in a series of Background Papers. The overview briefly describes key aspects of the region’s economy and development progress (Section 2). Next, in Section 3, it presents features of the economic geography of the region and some key results from economic modeling and transport connectivity analysis. The findings demonstrate the salience of the JET agenda in the Horn, and this and its implications are discussed in Section 4. Finally, Section 5 concludes by highlighting the main policy messages which emerge from the REM’s regional-level analysis.