Africa officially registered its first case of COVID-19 on February 14, 2020. On that day, the Egyptian Ministry of Health announced that a person was diagnosed with the virus at Cairo International Airport. On February 25, 2020, it was Algeria’s turn to confirm a case on its territory. This was followed by the other African countries throughout the month of March 2020. Instantly, the impact of the pandemic was felt both in terms of health, economy and social relations. On March 17, 2020, the African Union Commission decided to limit the number of employees coming to the office to prevent the spread of the virus. A rotation system and the tools to work remotely have been set up. In addition, various projects, meetings or initiatives had to be postponed. The organization adapted its operation in relation to the context. Despite the circumstances, the African Union does not intend to divert its efforts from its vision of “an Integrated, Prosperous and Peaceful Africa, driven by its own citizens and representing a dynamic force in the global arena.” The priority is currently to fight against the health catastrophe plaguing the continent. But this prioritization has the ultimate goal of being able to take advantage of the full potential of the continent to implement development actions despite the pandemic. In this perspective, this issue of SANKOFA aims to highlight the organization’s efforts to work for the African citizens even in times of crisis. And above all, it also seeks to pay tribute to all the staff members who are on the front lines of the fight against COVID-19.