Strains of the Aspergillus fungi, especially A. flavus and A. parasiticus, primarily produce aflatoxins which are a major health concern to man and livestock because of their acute and chronic health effects. Aflatoxins pose the greatest risk to health in tropical Africa because of their widespread prevalence and high toxicity; carcinogenic (cause liver and esophageal cancer) effect, immune system suppressing and anti-nutritional contaminants in many food commodities and even cause death. Aflatoxins have also been reported to compromise vaccine efficacy in experimental animals. Due to the seriousness of aflatoxins, international agencies have restricted levels of aflatoxins to 20 ppb in food materials as the maximum permissible level in the United States and 4 ppb total aflatoxins and under 2 ppb aflatoxin B1 in Europe. These regulations directed at minimizing human exposure to aflatoxins results in severe economic loss to producers, processors and marketers of the contaminated...
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