The years from 2017 to 2025 marked a transformative period for the African Union Commission (AUC) under the leadership of H.E. Chairperson Moussa Faki Mahamat. Amidst significant global and continental challenges, the AUC demonstrated resilience, innovation, and strategic action to address crises and opportunities under the guidance of the Heads of States and Governments of the African Union. Despite complex circumstances, the African Union Commission (AUC) demonstrated strong leadership during major health crises, particularly the COVID-19 pandemic, which tested Africa’s capacity for collective response. It emerged as a symbol of resilience and self-reliance, coordinating continent-wide efforts to manage the pandemic, procure vaccines, and build public health infrastructure. The AUC’s response to the growing impacts of major issues in the areas of peace and security, international governance, climate change, food insecurity and many other strategic issues reflected its commitment and resolve to be a key continental and global player through African-led initiatives. This era laid a strong foundation for accelerating the implementation of Africa’s development blueprint, Agenda 2063, and served as a pivotal transition from the first decade of Agenda 2063 (2014 - 2023) to the second (2023 - 2033), with a renewed focus on strengthening implementation mechanisms, achieving measurable outcomes, and fostering collective ownership ....