In 2021, West Africa continued to face protracted insecurity and political instability, with conflicts in Central Sahel and the Lake Chad Basin (Burkina Faso, Cameroon, Chad, Mali, the Niger and Nigeria). The impacts of such challenges were compounded by the socioeconomic consequences of the COVID-19 pandemic. Extreme poverty in the subregion increased by almost 3 percent in 2021 (COVID-19 West Africa Socio-Economic Impact Monitoring Report, released by the Economic Community of West African States). Consequently, the combined effects of these factors have led to a deterioration of food insecurity and malnutrition in the subregion, especially in conflict-affected areas. This publication gives an overview of the emergency and resilience activities implemented in West Africa in 2021.