This report provides an update on the progress made in the control of global priority transboundary animal diseases (TADs), which was presented by the disease working groups and secretariats at the Global Steering Committee meeting (GSC12), held during two sessions in November and December 2021. It presents a concise summary of activities carried out under the Global Framework for the Progressive Control of Transboundary Animal Diseases (GF-TADs) umbrella from November 2020 to October 2021. The TADs covered in the report include African swine fever, foot-and-mouth disease and peste des petits ruminants, as well as the rinderpest post-eradication programme. The main areas of focus include a summary of TADs control strategies, the epidemiological situation in the past two years, as well as the progress and challenges faced in the last year. Regional activities for the five main geographical regions of the GF-TADs are also highlighted in the report. Funding support for TADs control is presented in Annex I and a follow-up of the action plan developed following the recommendations of the third external evaluation of GF-TADs is presented in Annex II. Information on specific activities mentioned in the report can also be found through the dedicated sections of the GF-TADs website or by request from the GF-TADs global secretariat.