This publication provides reference and general guidance for countries, specifically policy makers and official, to draft and implement policies on antimicrobial resistance (AMR) and antimicrobial use (AMU) for food animal production within a One health Approach. It offers practical guide for countries to systematically identify, assess and strengthen AMR and AMU policies. The framework described in this publication is designed to help countries review their own national policies and provides examples from countries that facilitate effective national response to AMR.