Most private not-for-profit (PNFP) health providers in Uganda are faith-based. They account for a sizeable proportion of the health services delivered in the country and have as their prime concern the provision of services to the poor. These providers are coordinated through umbrella organizations, such as the Catholic, Protestant, and Muslim Medical Bureaus and the Uganda Community Based Health Care Association. This article documents the experiences of the Catholic health network in Uganda and its umbrella organization, the Uganda Catholic Medical Bureau (UCMB) in making health services work for poor people. It demonstrates how the pro-poor ethos derived from a longstanding tradition and the mission of healing by treating and preventing diseases, with a preferential option for the less privileged supported by soft regulation and technical assistance from the umbrella organization can induce a process of activity.